Twenty years after the events of The House of the Dead II, Lisa Rogan and Agent G are desperately searching for Lisa's father, Thomas. Eventually they find themselves at a local corporate office, which is over-run with all kinds of deadly and evil creatures of the afterlife.

It's up to you (or a friend) to blast your way through the evil dead to rescue Lisa's father. Included are multiple gameplay paths (you choose which way to go), the new auto-reloading shotgun, and 2 player support.