As the name suggests, Tetris Collection contains a number of Sega-published versions of Tetris, Flash Point and Bloxeed. Not only can the original arcade games be played, but you can also view arcade fliers and listen to the game's sounds from a special menu selected with Select.

Unique to this collection is the Sega Mega Drive port of Tetris, including full box and manual scans, and a prototype ROM of a cancelled Mega Drive port of Flash Point, both of which were prevented from being sold due to presumed licensing problems. It also appears to include a Sega System 16 version of Bloxeed; the situation behind this is unknown and needs to be investigated (TODO).

Brand new and exclusive to Tetris Collection is "Tetris New Century", which builds upon the 1988 System 16 version of Tetris. New Century implements many of the standards set by The Tetris Company, including the standardised colour scheme, wall kicks, being able to "hold" a piece and the "T-Spin" move (allowing you spin a T-tetromino to fill in gaps shortly before the piece locks into place).

Aesthetically, however, New Century is similar to the System 16 game, though is no longer bound by hardware limitations, meaning the monkey guide previously only seen in the attact mode appears throughout. The style of the blocks also changes as time goes on, in addition to backgrounds being swapped out.