Rune Factory: Tides of Destiny introduces you to two new protagonists, Aden and Sonja who, due to mysterious circumstances are two souls trapped in one body! They find themselves not only stuck together but transported to a strange new island and no way to get home. You must take the role of Aden and befriend the locals while exploring the oceans on your newly found Golem to find the truth and a way to restore Sonja back to her body. Besides exploration and fighting, the game allows you to perform various other activities such as farming, cooking, crafting and fishing.

Rune Factory: Tides of Destiny is the second of its series to be released on the Wii and the first on the PS3 and it brings many new enhancements. One of the newest additions is your Golem, which you will use to explore the ocean surrounding Fenith Island. The combat has been updated from that of Frontier, adding new weapons such as Dual Blades and Katanas. You now have the ability to unlock up to 4 farms, one for each season. The Winter farm acts as a Mine where you can harvest ores and gems while the other three stay true to the series by having seasonal crops such as Cabbage in Spring, Corn in Summer, and Eggplants in Fall. Nearly the entire game is now voice acted as well. While you can play as a Male, in the end game there is an option to take over playing as the Female protagonist and marry one of 4 male choices.