Touki Denshou: Angel Eyes is a 2D versus fighting game featuring an all-female cast, which plays much like contemporaries such as King of Fighters. A curious aspect of the game is that four of the eight regular characters are hand-animated sprites, while the other four are pre-rendered graphics as in Donkey Kong Country or Rise of the Robots.

In addition to the standard Arcade and Versus modes, the PlayStation release adds a dedicated Story mode for each character, plus a training mode. There also numerous secret characters to unlock, including 2D-sprite versions of some of the 3D characters, and the story mode bosses.