Mega Man Star Force 2: Zerker X Saurian, along with Zerker X Ninja, is the sequel to Mega Man Star Force. The story picks up a couple of months after the events of the first one, Geo Stelar and Omega-Xis return to thwart the plans of a mysterious organization who want to revive the ancient civilization of Mu. Also, a new rival character by the name of Rogue appears.

The sequel retains the gameplay and other aspects of it's predecessor, among the new additions is the Link Power, which as it increases, allows players using the Brother Band system to access treasure and ares inaccessible by those with less Link Power.