Azumanga Daioh Puzzle Bobble is a game based on the Azumanga Daioh anime and manga which was released by Taito Corporation as an arcade-only Puzzle Bobble spin-off on June 1, 2002. It was developed by MOSS for the Sega NAOMI GD-ROM arcade and distributed in Japan exclusively. It also has a two-player mode and the original voice actors from the Azumanga Daioh anime reprise their roles. It is controlled using one joystick and two buttons.

This game takes place during second year after Episode 12.