Similar to the movie Terminator, the aliens want to take over the world before Duke was even born and travel through time. Duke follows them and tries to stop their evil plan, chasing them through the wild west, the dark ages, victiorian London and finally the post apocalyptic world of the future.

Awesome new enemies! Hilarious gags and one-liners! Same blood and guts attitude! Over 30 gut-wrenching levels set in four action-packed time eras! Incredible Teamplay and Deathmatch modes for up to 4 players! Over 20 all-new weapons of high-octane annihilation.