In the sequel to Zombie Ate My Neighbors players control the kids Zeke and/or Julie, who travel to different worlds and fight skeletons, ghouls, ghosts, and other demonic creatures in order to save their town from a horror exhibit that came to life.

Shooting enemies with weapons like Plasma Gun or Lobbing Smash Gun, the heroes need to rescue ten trapped victims on each level and fight the boss at the end, all the whole conserving the limited ammunition.