In The Ren & Stimpy Show: Time Warp, the player takes command of the comedy duo on a quest through time to stop Stimpy's beloved hero, Muddy Mudskipper, from changing history and ruining space and time.

The game is a side-scrolling platformer mixed with side-scrolling shooting sequences where the player takes command of a space ship through time portals in between stages. There are five stages to play in: the backyard, the Big City, the Untamed World, a zoo and a haunted house. To defeat enemies on their way, Ren and Stimpy will find various crazy weapons like beaver saws and watermelon bows, as well as other items to help them out in their quest, such as rubber nipples used for climbing walls.

There are also various obstacles and traps the players must avoid, like the Crockostimpy and the Happy Helmet which will temporarily incapacitate the player until it is knocked off their head. The player can find health power-ups to restore their health and earn points by picking up money symbols. The game also features the voice talents of Billy West.