In the PSP game in the Dead to Rights series, you once again play as Jack Slate in the crime-infested Grant City where you have to save a girl that has been taken hostage. To do this, you need to fight gangs using both weapons and melee combat, combined with stylish moves such as slow motion dives. The main character is accompanied by his K-9 dog Shadow. Jack can disarm opponents and instruct Shadow to attack enemies.

Multiplayer games are available for up to four players. Although it is a completely new game, some levels, such as the Train Station, have been recycled from Dead to Rights II.