Tiny Toon Adventures: Defenders of the Universe is a cancelled and unpublished 2002 fighting game. Based on the Tiny Toon Adventures franchise, it was initially scheduled for release in Spring 2002, but was eventually cancelled for unknown reasons. It was developed by Treasure and it was originally slated for the PlayStation 2. Nintendo Power has listed this game in its publication, suggesting that there was also going to be a Nintendo Gamecube version.

The plot of Defenders of the Universe centers on Montana Max taking over the planet Gold Star. Natives of the planet, the Bullions, escape and ask Buster Bunny, Babs Bunny, Plucky Duck, and Hamton Pig for help.