Private Nurse Maria is the PlayStation 2 port of the Windows hentai visual novel Private Nurse. Aside from adding the name of the lead heroine to the game's title, all the adult content has been removed and the story adjusted accordingly so it works without it. The staff from the original release has been reassembled to update and polish the graphics, soundtrack, and the story scenario. Additionally, after the end game a bonus scenario becomes available which adds more to the story and overall gameplay. This release also includes a small band-aid pouch holding 10 band-aids, both items featuring artwork of a lead heroine Maria from the game.

Hiroki has been fighting sickness all his life, until one day when a mysterious nurse appears at his doorstep. She smiles and says, "You don't have to worry anymore. My name is Maria, your private nurse. I've come to cure you."