The game focuses on the lives of Nana Osaki, and Nana Komatsu, two girls who moved to Tokyo to make their dreams come true. Although, Nana and Hachi are prominant characters the game gives the player their own character, who lives next to the Nana's in Apt. 708. There are five choices of characters, all are uniquely designed by Ai Yazawa for the game.

The player gets to experience the storylines of volumes five through eight. Additionally, the player can meet other characters like, Ren Honjo, Takumi Ichinose, or Shinichi Okazaki, and the player can even date them. They also, can experience Tokyo life, for example getting part-time jobs, buying clothes, and decorating their room.