The latest entry in the highly successful Tiger Woods golf franchise from Electronic Arts, Tiger Woods PGA Tour 06 features 15 golf courses (11 real courses, 3 fantasy courses), 15 real golfers (including Tiger Woods and Vijay Singh), and 12 fantasy golfers. Courses can be "Tiger-proofed" to make them more challenging.

Players can work their way through a PGA career, they can chase Tiger Woods through all the major historical eras of golf, or they can engage in the usual array of game modes seen in previous entries in this series.