Izuna is back. After making friends with the six gods of Kamiari Village in the first game, she finds herself at the wedding of a friend. That night, Izuna's sister Shino goes missing, presumably kidnapped, and Izuna goes after her.

Izuna 2 is rather similar to the first game. You will once again descend into the depths of randomly-generated dungeons, risking your life at every turn. If you die, you'll lose everything except for your experience. New is the tag-team system, which can let you continue with another character after your death, Spirit Points, designed to give you a bit of urgency, and a tutorial.