Based off of the anime series of the same name, Inukami! is a visual novel with story, artwork, and voice acting to match the slapstick romantic comedy about a boy named Keita and his mischievous companion. In a world where demons with canine features known as Inukami exist, the Inukami tamers must rise up to tame them so that the Inukami shall protect humans with their power. Keita Kawahira, born from a long line of tamers, has only ever successfully managed to partner up with Youko, an uncontrollable yet powerful Inukami.

Play as Keita as he meets other Inukami and gets into trouble with Youko before his search for true love comes to an end. Collect cards during the adventure to unlock action, card fight, and trivia mini-games based on the story of Inukami!: battle using cards based on the characters with up to three friends, answer questions based on the story, and play through with songs such as the ending theme of the anime for the ultimate Inukami! experience.