Opoona, is a lifestyle RPG where the player takes command of a boy who is descended from a race of warriors called the Cosmo Guards, maintainers of the peace of the universe. While on a vacation with his family from his home planet Tizia, crash land on a mysterious planet called Landroll. When he awakes he finds out his parents are seriously injured and being taken care of at a local hospital and his brother and sister are somewhere lost on the vast planet.

After learning of his predicament, Opoona is determined to find them, but to travel from colony to colony on the planet, he must first obtain a license from the bureaucratic-choked colonies to travel between them. To do this, he must complete jobs in each colony, anything from fishing, a park ranger, a fortune teller, janitorial work to even fighting monsters like evil flat screen TVs.

To find these jobs, the player must travel around the homes, striking conversations with the people, making new friends and taking the odd jobs from them. The controls mostly consist of the Wii-remote to move around and the nunchuk to target enemies. To do this the player uses the nunchuk to target their enemy, set the trajectory and snap the nunchuk forwards to fling energy "bon-bons" at their opponents.

The player can also use money obtained through the various odd jobs to shop and collect various items throughout the planet, anything from toys to even great pieces of art. There is also a "friend-of-nature" theme, where the world of Landroll is in balance with the planet, combining nature and modern structures along with beautiful scenery such as jungles, ancient ruins and large forests.