The Drug Store: Matsumoto Kiyoshi de Okaimono! is a simulation game made by Human in which the player can build his own Drug Store shop. The first is to choose the proper place to do it, since the possible customers will depend of the place chosen to the shop. After building the shop the next step is to choose the proper furnitures and the goods that are going to be sold.

After all that choices the shop will be opened and the game features different announcements to make the shop more known so depending of how much money the player have the publicity will be more effective and bring more customers.

The game features some events like conversations with some people in first person perspective with anime 2d cartoon designs.