Germs is a first person perspective adventure shooter game that takes place in a futuristic city in which the player takes the role of a reporter of the Daily City-Net that is investigating some strange incidents that happened lately in the city, during the adventure he will have to gather information to advance in the story and face some different enemies that seems to have suffer an strange mutation.

The gameplay is going around the town and gather information talking to people and using items, to go around the city the player can use the public transport (like bus) or drive a car.