Mega Monster Battle: Ultra Coliseum is the first Ultra Galaxy video game released for Wii only. It's released to coincide the series Ultra Galaxy Mega Monster Battle: Never Ending Odyssey. This game is succeeded by Mega Monster Battle: Ultra Coliseum DX: The Gathering of The Ultra Heroes!

You have to use the Wii Remote and Nunchuk to play this game. Various monsters are confirmed and playable in this game including: Gomora, Alien Metron, Black King and Reimon. You have to use team formation in playing it. Each team has a maximum of 3 Kaiju. There is a combo called "Ultra Combo". In "Ultra Combo", you can use each character's card and you can activate it. Each character has its own elemental attacks for example just Eleking. If you use the Eleking card, you will activate the effect.

Now for playing, each player has a strength bar that will continuously increase and decrease. The player must move their Nunchuk at the right time to get a higher attack point. After that, both players must move rapidly their Nunchak in the shoulder rush part. The attack point is you point differences with enemies' point after shoulder rush. The player that wins the shoulder rush can determine their attack, which can be: punch or kick, summon partner, or use a partner card effect. For punch or kick you must press B button at right timing to damage the opponent in certain period.