Roger Wilco, the brave interstellar janitor who has already saved the universe from many great dangers, is now in a very embarrassing position. His commanders show no respect for his courageous actions in the previous game. Instead, he is being accused of all kinds of violations against the galactic law, is deprived of all the honors he got in the previous game, and as a token of mercy, is allowed to return to his old job - cleaning closets... But those unfortunate events are just the beginning of much bigger troubles Roger will get into. Once again, the future of galaxy depends on him!

Space Quest 6 is the first game in the series to be released exclusively on a CD ROM. The game continues the humorous tradition of the series and is especially inclined towards parody of popular sci-fi movies. It features SVGA graphics and voice-overs for conversations and text descriptions. The interface is slightly different from icon-based system used by Sierra in many other adventure games: the player chooses verbs from a menu that appears at the bottom of the screen, similarly to earlier LucasArts titles. Unlike all previous Space Quest installments, the game allows the player to retry immediately in case Roger dies, without the need to restore a previously saved game.