In Purikura Daisakusen, the Miracle Kingdom has been invaded by an evil mechanical army, all of its inhabitants have been magically transformed into animals, and the queen has been imprisoned. Taking on the role of either the gallant knight Grey, or one of the queen's sisters Kurara or Kirara, the player must reach the queen and save the land while demolishing any creature that stands in their way.

The game plays as an isometric scrolling shooter, in which the player must navigate their chosen character through stages, killing enemies with magic attacks while collecting power-ups and other unique items. Attacks can be melee or ranged, with each being capable of being upgraded via power-ups, and a dodge ability allows the player to avoid most basic attacks. Each character also has a "super" form, which becomes available with enough magic energy.

The player also has a familiar with them at all times, which gradually evolves and increases its powers with each enemy defeated. Features simultaneous 2-player cooperative gameplay and a bonus gallery mode with a fully-voiced commentary option.