Naruto: Uzumaki Chronicles 2 is the sequel to Naruto: Uzumaki Chronicles and is based off of the animated TV series Naruto. The Five Great Nations are exposed to an army of living dolls called Puppet Walkers, who are attacking villages and obtaining "Spirit Orbs". Naruto Uzumaki and his friends have to stop the Puppet Walkers from getting the last of five Spirit Orbs.

Unlike its predecessor, Naruto: Uzumaki Chronicles 2 is not mission-based. The game plays similar, though. The versus mode and the mission mode have a lot of replayability, despite Uzumaki Chronicles 2 being a shorter game to beat. Sasuke and Kakashi are playable in the game as well, depending on the actions taken by the player.