In Maria : Kimitachi ga Umareta Wake, you play as a young psychiatrist named Takano. One day a new patient is brought into the hospital you work in - Maria, a young woman who has attempted suicide. She suffers from amnesia, and you try to find out more about her, visiting her and talking to her. Before long you discover that Maria has schizophrenia - a split personality. Her "other self" appears to be evil and threatens to take over her. The fight for Maria's sanity begins.