L.A. Machineguns is a 3D lightgun shooter played from a first-person perspective. In Los Angeles at 2025, the US President is kidnapped by androids. Two S.I.F.A.T. agents have been dispatched to rescue the president and neutralize the threat at Alcatraz, Las Vegas and then finally Yosemite to eliminate the leader. The requires the player(s) to shoot as many enemy targets in the shortest amount of time and avoid getting hit by enemy opponents and taking care not to hit innocent bystanders. Sometimes critical hits are marked allowing for maximum damage. At the end of each level, the player must destroy a boss vehicle to proceed.