Giana's Return is an unofficial fan-made sequel to the classic Great Giana Sisters. The Evil Swampy has stolen the magic ruby, which enabled Giana and her sister Maria to wake up from their dream in the first game. Moreover, Swampy has fallen in love with Maria and kidnapped her. It is now up to Giana to go back to the dream land to rescue Maria and get back the ruby.

The game, like its predecessor, is a classic 2D side scroller. Giana needs to pass through various levels in seven different worlds. She can jump on enemies to kill them, or find a magic ball which turns her into Punk Giana, who can shoot enemies with fire balls.